Since the early 1900s, scientists have been using conventional 2D cell culture to study human biology and have made significant progress in the field. However, the limitations of this method, such as the use of cancerous cell lines, static microenvironments, and limited cellular complexity, have become apparent over time. These limitations hinder the ability of 2D cell culture to accurately model human diseases and predict human responses to drug candidates.
In response to these limitations, Organ-Chips have been developed as an innovative cell culture technology. These advanced in vitro models provide a more human-relevant platform for disease research and drug discovery and development. By replicating the microenvironment that cells experience within the human body, Organ-Chips offer a more authentic representation of human responses compared to traditional 2D cell culture.
Luke Dimasi, Senior Director of Product Management at Emulate, provides an overview of the Emulate Organ-on-a-Chip technology in this webinar. He explores the advantages of Organ-Chips over 2D cell culture and shares data-driven examples that demonstrate their enhanced physiological relevance. Organ-Chips offer a promising solution for overcoming the limitations of 2D cell culture and advancing research in human biology.